Oxycodone has been in clinical use since 1917. Buy Oxycodone Oxycontin 30mg online in Australia
It has been administered to human beings intravenously (i.v.),
and orally using immediate-release solutions, and immediate- and controlled-release tablets. Buy Oxycodone Oxycontin 30mg online in Australia
The transdermal route of administration has also been tested in animals.
It was used in northern Europe mainly for acute pain. In Canada, Australia, and the United States, it was used mainly as a combination drug with acetaminophen, phenacetin, and caffeine for moderate pain. In Finland, oxycodone has been used as the main parenteral opioid for acute pain since the 1960s. Buy Oxycodone Oxycontin 30mg online in Australia
Chemistry and Basic Pharmacology
-opioid receptor. Buy Oxycodone Oxycontin 30mg online in Australia
The μ-opioid receptor binding affinity of oxycodone is, however, less than that of morphine or methadone.
Oxymorphone, the active metabolite of oxycodone, has a significantly higher μ-opioid receptor binding affinity.
Intramuscular oxymorphone and morphine were compared in patients with chronic pain due to cancer. Intramuscular oxymorphone proved to be 8.7 times as potent as morphine in terms of total analgesic effect and 13 times as potent in terms of peak effect.
After systemic administration (subcutaneous or intraperitoneal), oxycodone was shown to be 2–4 times more effective than morphine. Buy Oxycodone Oxycontin 30mg online in Australia
These results have indicated that the active metabolites of oxycodone (e.g., oxymorphone) could be important in oxycodone-mediated analgesia. Studies using Dark Aguti rats that are deficient in the enzyme CYP2D1, which is required to O-demethylate oxycodone in the rat, and various opioid receptor antagonists have suggested that the antinociceptive effects of oxycodone could be κ-opioid receptor–mediated.