Clonazepam is a long-acting and high-potency benzodiazepine. It behaves as a GABA-A receptor agonist. It also has serotonergic activity by increasing serotonin synthesis. Clonazepam has anticonvulsant and anxiolytic effects. It is FDA-approved for the treatment of seizure disorders and panic disorders. It also has off-label use as monotherapy or adjunctive therapy to treat mania, restless leg syndrome, insomnia, tardive dyskinesia, and REM sleep behavior disorder. Buy Rivotril clonazepam 2mg online in Australia
Clonazepam has a broad range of activities against different types of seizure disorders. Its primary indications are acute management of epilepsy and acute treatment of non-convulsive status epilepticus (complex partial seizures or absence seizures). It is also very effective in controlling the minor motor seizures of childhood, particularly petit mal absences, Lennox-Gastaut syndrome, and infantile spasm. Clonazepam is also useful in the treatment of psychomotor, myoclonic epilepsies, grand mal, and focal motor seizures. However, it is not used as first-line therapy for these conditions. It can be used in patients resistant to standard treatment. Buy Rivotril clonazepam 2mg online in Australia
Clonazepam causes a significant improvement in patients who have panic disorders with or without agoraphobia. It is efficacious in the short-term management of panic disorder due to the risk of developing withdrawal symptoms and abuse. However, it is also less likely to cause rebound anxiety upon cessation than other benzodiazepines because of its longer half-life. Clinicians also use it for the acute treatment of panic attacks. Buy Rivotril clonazepam 2mg online in Australia
Clonazepam has anticonvulsant and serotonin agonist activity, both of which are associated with its antimanic effect. Therefore, it is sometimes helpful for the treatment of acute mania. The research found it to be significantly more effective than lithium in reducing manic symptoms, and fewer patients required PRN administration of haloperidol, as well as the number of days on which haloperidol was needed, was lower during clonazepam treatment. This way, the clonazepam reduces the need for antipsychotic drugs in the treatment of acute mania and decreases the risk of side effects in these patients. Nowadays, a combination of a benzodiazepine and the antipsychotic haloperidol is considered the most effective treatment of acute agitation in the emergency department. Buy Rivotril clonazepam 2mg online in Australia
Clonazepam is also an option for treating akathisia, restless leg syndrome, rapid eye movement behavior disorder, and bruxism. Buy Rivotril clonazepam 2mg online in Australia
Mechanism of Action
Clonazepam is highly potent and a long-acting benzodiazepine. It exerts pharmacological effects by acting as a positive allosteric modulator on GABA-A receptors. The GABA-A receptor is a ligand-gated chloride ion-selective channel which endogenous ligand is GABA (gamma-aminobutyric acid). Benzodiazepines (BZDs) facilitate GABA-A action by increasing the frequency of chloride channel opening resulting in hyperpolarization of the neurons and decreased firing, thus producing calming effects on the brain by reducing the excitability neurons. Buy Rivotril clonazepam 2mg online in Australia
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